Pitfalls in the measurement of tissue DDAH activity: is DDAH sensitive to nitrosative and oxidative stress?
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چکیده
منابع مشابه
DDAH says NO to ADMA.
Endothelium-derived nitric oxide (NO) is vasoprotective, as it enhances endothelial cell survival and proliferation, inhibits the excessive proliferation of vascular smooth muscle cells, and suppresses the adhesion of platelets and inflammatory cells to the vessel wall.1 Substantial evidence from preclinical studies and human research indicates that impairment of the endothelial NO synthase (NO...
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Objective(s): Reperfusion of ischaemic myocardium results in reduced nitric oxide (NO) biosynthesis by endothelial nitric oxide synthase (eNOS) leading to endothelial dysfunction and subsequent tissue damage. Impaired NO biosynthesis may be partly due to increased levels of asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of eNOS. As dimethylarginine dimet...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/ki.2008.360